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Fundamentals of Physics and Chemistry of the Atmosphere
Additive and Cancellative Interacting Particle Systems (Lecture Notes in Mathematics) by David Griffeath (Repost)
PI and the AGM: A Study in Analytic Number Theory and Computational Complexity by Jonathan M. Borwein (Repost)
Advances in Complex Function Theory (Lecture Notes in Mathematics) by W. E. Kirwan (Repost)
Synthetic inorganic chemistry a course of laboratory and classroom study by Arthur Alphonzo Blanchard (Repost)
Invitation to Law and Society - An Introduction to the Study of Real Law
Matrix Mathematics - Theory, Facts, and Formulas, Second Edition
Mathematics Probability, Markov Chains, Queues, and Simulation - The Mathematical Basis of Performance Modeling
-Physics, Topology, Logic and Computation: A Rosetta Stone- by John C. Baez adn Mike Stay
-Quantum Physics for Scientists and Technologists- by Paul Sanghera (Repost)
Algebraic Aspects of Cryptography (Algorithms and Computation in Mathematics) by Neal Koblitz (Repost)
Mathematics Mathematical Foundations of Computer Science 2004 [Repost]
Mathematics Mathematical Logic for Computer Science (3rd edition)
Physics Democracy and Public Space: The Physical Sites of Democratic Performance
Spaces of Holomorphic Functions in the Unit Ball (Graduate Texts in Mathematics) by Kehe Zhu (Repost)
An Introduction to Ergodic Theory (Graduate Texts in Mathematics) by Peter Walters (Repost)
Statistical and Thermal Physics - With Computer Applications
Introduction to the Physics of the Earth's Interior (Cambridge Topics in Mineral Ph) by Jean Paul Poirier (Repost)
Mathematics Symmetry Theory in Molecular Physics with Mathematica: A new kind of tutorial book (Repost)
THE GNOMON WORKSHOP CREATING A 3D FIGURE STUDY BOOKWARE ISO-LZ0
Additive and Cancellative Interacting Particle Systems (Lecture Notes in Mathematics) by David Griffeath (Repost)
PI and the AGM: A Study in Analytic Number Theory and Computational Complexity by Jonathan M. Borwein (Repost)
Advances in Complex Function Theory (Lecture Notes in Mathematics) by W. E. Kirwan (Repost)
Synthetic inorganic chemistry a course of laboratory and classroom study by Arthur Alphonzo Blanchard (Repost)
Invitation to Law and Society - An Introduction to the Study of Real Law
Matrix Mathematics - Theory, Facts, and Formulas, Second Edition
Mathematics Probability, Markov Chains, Queues, and Simulation - The Mathematical Basis of Performance Modeling
-Physics, Topology, Logic and Computation: A Rosetta Stone- by John C. Baez adn Mike Stay
-Quantum Physics for Scientists and Technologists- by Paul Sanghera (Repost)
Algebraic Aspects of Cryptography (Algorithms and Computation in Mathematics) by Neal Koblitz (Repost)
Mathematics Mathematical Foundations of Computer Science 2004 [Repost]
Mathematics Mathematical Logic for Computer Science (3rd edition)
Physics Democracy and Public Space: The Physical Sites of Democratic Performance
Spaces of Holomorphic Functions in the Unit Ball (Graduate Texts in Mathematics) by Kehe Zhu (Repost)
An Introduction to Ergodic Theory (Graduate Texts in Mathematics) by Peter Walters (Repost)
Statistical and Thermal Physics - With Computer Applications
Introduction to the Physics of the Earth's Interior (Cambridge Topics in Mineral Ph) by Jean Paul Poirier (Repost)
Mathematics Symmetry Theory in Molecular Physics with Mathematica: A new kind of tutorial book (Repost)
THE GNOMON WORKSHOP CREATING A 3D FIGURE STUDY BOOKWARE ISO-LZ0
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Study Microbial Protein Toxins
Posted on 2010-10-04
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Diphtheria toxin remains one of the most successfully studied of the bacterial protein toxins. A detailed understanding of the structure function relationships of the toxin and the role of each domain in the intoxication process is well understood. This understanding has led to the development of diphtheria toxin-related fusion protein toxins which are targeted toward specific cell surface receptors. The first of these targeted toxins are now approved for human clinical use in the treatment of refractory hematologic malignancies and graft-versus-host disease. In recent years, studies on the molecular mechanism by which the diphtheria toxin catalytic domain is translocated across the early endosomal membrane has revealed that a host cell cytosolic translocation factor complex facilitates the entry process. A detailed understanding of this process will further stimulate the development of new approaches toward the delivery of cargo, ranging from protein to nucleic acid and/or protein nucleic acids, to the eukaryotic cell cytosol.
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