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Study The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (repost)

Posted on 2010-03-16




Name:Study The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (repost)
ASIN/ISBN:1588295680
Language:English
File size:10.7 Mb
Language: English
Publish Date: 2006-06-01
ISBN: 1588295680
Pages: 640 pages
File Type: PDF
File Size: 10,7 MB
Other Info: Humana Press
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Bryan L. Roth "The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics"

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

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