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Nucleic Acids in Innate Immunity

Description: Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.

Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.

The second section focuses on the therapeutic applicationsof immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.

The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation.

Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

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	Radiation Induced Molecular Phenomena in Nucleic Acids: A Comprehensive Theoretical and Experimental Analysis (2008) Radiation Induced Molecular Phenomena in Nucleic Acids: A Comprehensive Theoretical and Experimental AnalysisPublisher: Springer \| English \| ISBN: 1402081839 \| 600 pages \| Data: 2008 \| PDF \| 13 MbDescription: Comprehensive theoretical and ...
	Science/Engineering Trends in Innate Immunity (2008) Trends in Innate ImmunityPublisher: S. Karger AG \| English \| ISBN: 3805585489 \| 211 pages \| 2008 \| PDF \| 4 MbDescription: The last decade has witnessed the delineation of innate immunity a new area which has revolutionized our understanding ...
	Science/Engineering Molecular Aspects of Innate and Adaptive Immunity Kenneth B. M. Reid, Robert B. Sim, "Molecular Aspects of Innate and Adaptive Immunity"Royal Society of Chemistry \| 2008-10-24 \| ISBN: 0854046984 \| 260 pages \| PDF \| 9.8 MBThis book provides a survey of topics, in the area of innate and adap ...
	Science/Engineering Innate Immunity (Methods in Molecular Biology) Jonathan Ewbank, Eric Vivier "Innate Immunity (Methods in Molecular Biology)"Humana Press \| 2007-11-19 \| ISBN: 1588297462 \| 300 pages \| PDF \| 6,6 MBImmunologists today are interested in all of the diverse cell-types involved in host defense ...
	Medical Innate and Adaptive Immunity in the Tumor Microenvironment Author: Eitan YefenofPublisher: SpringerPublish Date: Jan 2008ISBN: 1402067496Pages: 216Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one han ...
	Innate and Adaptive Immunity in the Tumor Microenvironment (US$159) Innate and Adaptive Immunity in the Tumor Microenvironment (US$159)Stationary Office \| Pages: 212 \| 2008-02 \| ISBN: 1402067496 \| 2 MB \| Rapidshare and Megaupload Cancer cells are continuously interacting with the immune system of the host. ...

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	Radiation Induced Molecular Phenomena in Nucleic Acids: A Comprehensive Theoretical and Experimental Analysis (2008) Radiation Induced Molecular Phenomena in Nucleic Acids: A Comprehensive Theoretical and Experimental AnalysisPublisher: Springer \| English \| ISBN: 1402081839 \| 600 pages \| Data: 2008 \| PDF \| 13 MbDescription: Comprehensive theoretical and ...
	Science/Engineering Trends in Innate Immunity (2008) Trends in Innate ImmunityPublisher: S. Karger AG \| English \| ISBN: 3805585489 \| 211 pages \| 2008 \| PDF \| 4 MbDescription: The last decade has witnessed the delineation of innate immunity a new area which has revolutionized our understanding ...
	Science/Engineering Molecular Aspects of Innate and Adaptive Immunity Kenneth B. M. Reid, Robert B. Sim, "Molecular Aspects of Innate and Adaptive Immunity"Royal Society of Chemistry \| 2008-10-24 \| ISBN: 0854046984 \| 260 pages \| PDF \| 9.8 MBThis book provides a survey of topics, in the area of innate and adap ...
	Science/Engineering Innate Immunity (Methods in Molecular Biology) Jonathan Ewbank, Eric Vivier "Innate Immunity (Methods in Molecular Biology)"Humana Press \| 2007-11-19 \| ISBN: 1588297462 \| 300 pages \| PDF \| 6,6 MBImmunologists today are interested in all of the diverse cell-types involved in host defense ...
	Medical Innate and Adaptive Immunity in the Tumor Microenvironment Author: Eitan YefenofPublisher: SpringerPublish Date: Jan 2008ISBN: 1402067496Pages: 216Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one han ...
	Innate and Adaptive Immunity in the Tumor Microenvironment (US$159) Innate and Adaptive Immunity in the Tumor Microenvironment (US$159)Stationary Office \| Pages: 212 \| 2008-02 \| ISBN: 1402067496 \| 2 MB \| Rapidshare and Megaupload Cancer cells are continuously interacting with the immune system of the host. ...

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