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Technical Neuroendocrine Cells and Peptidergic Innervation in Human and Rat Prostrate By Luis Santamaría
Posted on 2010-09-02
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More Neuroendocrine Cells and Peptidergic Innervation in Human and Rat Prostrate By Luis Santamaría, Ildefonso Ingelmo, Lucía Alonso, José Manuel Pozuelo, Rosario Rodríguez The prostate hosts an important amount of neuroendocrine cells which origin and functional role need to be better addressed. These cells synthesize and deliver a number of neurosecretory substances (serotonin, neuropeptides) having regulative activities over growth, cell differentiation, and secretion and might have a remarkable influence in the development of prostatic proliferative disorders such as hyperplasia or cancer. Moreover, the autonomous nervous system seems to be relevant in the maintenance of structural and functional integrity of the prostate, a wide variety of peptidergic fibres has been described in the prostate gland; such as neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP) nerves, etc. There is evidence about morphologic and functional relationships between neuroendocrine cells and prostate nerve fibres, resulting in a neuro-hormonal system that might modulate the androgenic action on the prostate.
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