Science/Engineering Drug Absorption Studies: In Situ, In Vitro and In Silico Models (Biotechnology: Pharmaceutical Aspects) (0387749004)

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Carsten Ehrhardt, Kwang-Jin Kim, "Drug Absorption Studies: In Situ, In Vitro and In Silico Models (Biotechnology: Pharmaceutical Aspects)"

In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.

Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.

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	Medical Prodrugs: Challenges and Rewards, 2 Volume Set (Biotechnology: Pharmaceutical Aspects) - ONLY Vol 1 ===Pharmaceutical
	Medical Prodrugs: Challenges and Rewards, (Biotechnology: Pharmaceutical Aspects) Publisher: Springer; 1 editionLanguage: englishISBN: 038749782XPaperback: 1470 pagesData: March 12, 2007Format: PDFDescription: Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the a ...
	Science/Engineering Prodrugs: Challenges and Rewards, 2 Volume Set(Biotechnology: Pharmaceutical Aspects) Prodrugs: Challenges and Rewards, 2 Volume Set(Biotechnology: Pharmaceutical Aspects)Stationary Office \| Pages:1740 \| 2007-03-12 \| ISBN: 038749782X \| 13 MBProdrugs: Challenges and Rewards, 2 Volume Set(Biotechnology: Pharmaceutical Aspects) ...
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	Science/Engineering Membrane Transporters as Drug Targets (Pharmaceutical Biotechnology) Membrane Transporters as Drug Targets (Pharmaceutical Biotechnology) Springer \| January 2000 \| ISBN-10: 0306460947 \| 544 pages \| PDF \| 2.9 mbBecause progress in the field of transporters has been extraordinary, this volume will focus on re ...

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