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Oral Drug Absorption: Prediction and Assessment (Drugs and the Pharmaceutical Sciences)

A practical, hands-on guide for successfully developing oral drug products, this comprehensive reference runs the gamut from theoretical stages of computer-based calculations to practical guidelines for establishing in vitro/in vivo correlations. Coverage details the interrelationship between the physiology of the gastrointestinal tract and oral drug formulations and absorption, and progresses to the latest applications of pharmacokinetic analysis. Includes chapters by the innovators of the Biopharmaceutical Classification Scheme (BCS), human perfusions, and biorelevant dissolution testing! With over 600 literature references, equations, drawings, and photographs, Oral Drug Absorption · offers multiple methods for predicting permeability, solubility, and dissolution for oral bioavailability and bioequivalence · facilitates selection of appropriate drug candidates for development · fully elaborates on the experimental and data analysis techniques of in vitro/in vivo correlations · provides guidance to the Federal Drug Administration's BCS and its applications · appends helpful case studies to the concepts discussed · and much more! Contributions by more than 20 international specialists on the latest research make Oral Drug Absorption an invaluable tool and useful reference in the hands of pharmaceutical scientists, medicinal chemists, pharmacists, pharmacologists, toxicologists, biochemists, gastroenterologists, regulatory personnel, and graduate school students in these disciplines.

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