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Cyclodextrins as new formulation entities and therapeutic agents
Posted on 2010-04-15
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Sreevalli Sikharam, Talmage D. Egan and Steven E. Kerna Cyclodextrins are well-known excipients in thepharmaceutical industry. Their recent application to the anesthetic induction agent propofol as a means of creating a non-lipid formulation may lead to their introduction into anesthesia pharmacology. The development of a novel cyclodextrin as specific reversal agent for the neuromuscular blocker rocuronium (that acts as an in-vivo scavenging system to bind free rocuronium in the circulation) will also increase the likelihood that cyclodextrins will have a greater clinical presence in anesthesiology in the future. Cyclodextrin-containing polymers are also finding a role in the delivery of nucleic acids and protein therapeutic agents. Summary Recent developments in cyclodextrins as excipients for anesthetics may soon culminate in their introduction into anesthesiology, although more research is necessary to better define their potential. Keywords bioavailability, cyclodextrins, formulation, solubility Curr Opin Anaesthesiol 18:392C395. 2005 (˵: )
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