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Annual Reports in Medicinal Chemistry, Volume 36 (Annual Reports in Medicinal Chemistry) By Annette M. Doherty

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an

emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies.

Volume 36 retains the familiar format of previous volumes, this year with 30 chapters. Sections I-IV are disease-oriented and generally report on specific

medicinal agents with updates from Volume 35 on antitussive therapy, anticoagulants, antibacterials, and antiretroviral therapies. As in past volumes,

annual updates have been limited to the most active areas of research in favor of specifically focused and mechanistically oriented chapters, where the objective is to provide the reader with the most important new results in a particular field.

Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design as well as the critical interfaces among these

disciplines. Included in Section V, Topics in Biology, are chapters on bioinformatics, protein structure prediction, proteonomics, and therapeutic antibodies. Chapters in Section VI, Topics in Drug Design and Discovery, reflect the current focus on mechanism-directed drug discovery and newer technologies. These include chapters on aspartyl protease inhibitors, ADME by computer, PET ligands for assessing receptor occupancy in viva, and strategies for analytical characterization and profiling of compound libraries.

Volume 36 concludes with To Market, To Market - 2000, a chapter on NCE and NBE introductions worldwide in 2000 and chapters on new developments in

animal health care and the impact of intellectual property issues on the pharmaceutical industry. In addition to the chapter reviews, a comprehensive set

of indices has been included to enable the reader to easily locate topics in Volumes 1-35 of this series.

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