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Annual Reports in Medicinal Chemistry, Volume 35 (Annual Reports in Medicinal Chemistry)

by Annette M. Doherty (Editor), William K. Hagmann (Series Editor)

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies.

Table of Contents

Contributors Preface 1 Current and Emerging Opportunities for the Treatment of Neuropathic Pain 1 2 Neuropeptide Receptor Antagonists for CNS Disorders 11 3 Metabotropic Glutamate Receptors: Agonists, Antagonists, and Allosteric Modulators 21 4 Melanocortin-4 Receptor Agonists and Antagonists: Chemistry and Potential Therapeutic Utilities 31 5 Secretase Inhibitors for Alzheimer's Disease 41 6 Urinary Incontinence: Neuropharmacological Approaches 51 7 Recent Developments in Neuropeptide Y Receptor Modulators 61 8 Modulators of Peroxisome Proliferator-Activated Receptors (PPARs) 71 9 Ghrelin Receptor Modulators 81 10 Current and Future Gastrointestinal Prokinetic Agents 89 11 Urotensin-II Receptor Modulators 99 12 Bradykinin-1 Receptor Antagonists 111 13 A[subscript 3] Adenosine Receptors 121 14 CCR3 Antagonists for the Treatment of Respiratory Diseases 131 15 Emerging Opportunities for the Treatment of Inflammatory Bowel Disease 141 16 TNF-[alpha] Converting Enzyme (TACE) as a Therapeutic Target 153 17 Progress in Antifungal Drug Discovery 163 18 Recent Advances in the Chemotherapy of HIV 173 19 Antibacterial Treatment of Community-Acquired Respiratory Tract Infections 183 20 Beyond Kinases: Purine-Binding Enzymes as Cancer Targets 193 21 New Therapies for Malaria 203 22 Non-HIV Antiviral Agents 213 23 Recent Advances in Antibody Drug Conjugates for Cancer Therapy 229 24 Obesity Therapeutics: Prospects and Perspectives 239 25 SNPs: A human genetic tool for the new millennium 249 26 RNAi: When Interfering Is a Plus 261 27 Lipid Rafts in Immune Cell Signaling 275 28 Recent development in Cheminformatics and Chemogenomics 285 29 Disruption of Protein-Protein Interactions 295 30 Recent Advances in Virtual Ligand Screening 305 31 Enzyme Induction - Mechanisms, Assays, and Relevance to Drug Discovery and Development 315 32 The use of bioisosteric groups in lead optimization 333 33 To Market, To Market - 2002 347 34 Health and Climate Change: Implications for the Pharmaceutical Sector 375 35 Pharmaceutical Productivity - The Imperative for New Paradigms 383 Compound Name, Code Number and Subject Index, Volume 38 397 Cumulative Chapter Titles Keyword Index, Volumes 1-38 407 Cumulative NCE Introduction Index, 1983-2002 425 Cumulative NCE Introduction Index, 1983-2002, by Indication 443

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