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H. Richard Leuchtag “Voltage-Sensitive Ion Channels: Biophysics of Molecular Excitability"

Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book critically examines physically oriented approaches not covered in other ion-channel books. It looks at optical and thermal as well as electrical data, and at studies in the frequency domain as well as in the time domain. Rather than presenting the reader with only an option of mechanistic models at an inappropriate pseudo-macroscopic scale, it emphasizes concepts established in organic chemistry and condensed state physics. The book s approach to the understanding of these unique structures breaks with the unproven view of ion channels as structurally gated pores. Rather, it proposes gateless gating, in which the onset and cessation of avalanches of ions crossing the membrane is explained as a cooperative phenomenon in a system poised far from equilibrium. These events, called channel opening and closing, are initiated by an electrical depolarization, a mechanical stimulus or even a thermal fluctuation.

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	Science/Engineering Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels Valentin K. Gribkoff, Leonard K. Kaczmarek, “Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels” Wiley \| 2009-02-09 \| ISBN: 047193013X \| 496 pages \| PDF \| 7,8 MB This book discusses voltage-gated ion channels and ...
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	Science/Engineering Voltage-Gated Ion Channels as Drug Targets Voltage-Gated Ion Channels as Drug TargetsPublisher: Wiley \| Pages: 492 \| 2006-04-17 \| ISBN 3527312587 \| PDF \| 4 MBEdited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resourc ...
	Science/Engineering Voltage-Gated Calcium Channels (Molecular Biology Intelligence Unit) by Gerald Werner Zamponi Voltage-Gated Calcium Channels (Molecular Biology Intelligence Unit) by Gerald Werner ZamponiPublisher: Springer \| February 10, 2005 \| ISBN: 0306478404 \| Pages: 377 \| PDF \| 28.72 MBVoltage Gated Calcium Channels is the first comprehensive b ...
	Science/Engineering Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels (Repost) Valentin K. Gribkoff, Leonard K. Kaczmarek, "Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels" Wiley 2009 \| ISBN: 047193013X \| 496 pages \| PDF \| 7,9 MB This book discusses voltage-gated ion channels and their i ...
	Science/Engineering Fractals in Molecular Biophysics T. Gregory Dewey, "Fractals in Molecular Biophysics"Oxford University Press \| ISBN: 0195084470 \| 1 edition (January 15, 1998) \| PDF \| 288 pages \| 13973 KB “Historically, science has sought to reduce complex problems to their simplest ...

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	Science/Engineering Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels Valentin K. Gribkoff, Leonard K. Kaczmarek, “Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels” Wiley \| 2009-02-09 \| ISBN: 047193013X \| 496 pages \| PDF \| 7,8 MB This book discusses voltage-gated ion channels and ...
	Science/Engineering Introduction to Molecular Biophysics Introduction to Molecular BiophysicsPublisher: CRC \| Pages: 584 \| 2003-02-26 \| ISBN 0849300398 \| PDF \| 12 MBMolecular biophysics is a rapidly growing field of research that plays an important role in elucidating the mysteries of life's mol ...
	Science/Engineering Voltage-Gated Ion Channels as Drug Targets Voltage-Gated Ion Channels as Drug TargetsPublisher: Wiley \| Pages: 492 \| 2006-04-17 \| ISBN 3527312587 \| PDF \| 4 MBEdited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resourc ...
	Science/Engineering Voltage-Gated Calcium Channels (Molecular Biology Intelligence Unit) by Gerald Werner Zamponi Voltage-Gated Calcium Channels (Molecular Biology Intelligence Unit) by Gerald Werner ZamponiPublisher: Springer \| February 10, 2005 \| ISBN: 0306478404 \| Pages: 377 \| PDF \| 28.72 MBVoltage Gated Calcium Channels is the first comprehensive b ...
	Science/Engineering Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels (Repost) Valentin K. Gribkoff, Leonard K. Kaczmarek, "Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels" Wiley 2009 \| ISBN: 047193013X \| 496 pages \| PDF \| 7,9 MB This book discusses voltage-gated ion channels and their i ...
	Science/Engineering Fractals in Molecular Biophysics T. Gregory Dewey, "Fractals in Molecular Biophysics"Oxford University Press \| ISBN: 0195084470 \| 1 edition (January 15, 1998) \| PDF \| 288 pages \| 13973 KB “Historically, science has sought to reduce complex problems to their simplest ...

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