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The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (Proteins and Cell Regulation)

Posted on 2010-03-16




Name:The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (Proteins and Cell Regulation)
ASIN/ISBN:1402065604
Language:English
File size:3.57 Mb
Publisher: Springer
ISBN: 1402065604
Publish Date: edition 2007
File Type: PDF
Pages: 328 pages
File Size: 3,57 mb
   The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (Proteins and Cell Regulation)



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Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few mad scientists searching for natural substrates.

Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.

In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.

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