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T Cell Activation by CD1 and Lipid Antigens (Current Topics in Microbiology and Immunology)

Posted on 2010-04-14




Name:T Cell Activation by CD1 and Lipid Antigens (Current Topics in Microbiology and Immunology)
ASIN/ISBN:3540695109
Language:English
File size:3.44 Mb
Publisher: Springer
ISBN: 3540695109
Publish Date: edition 2007
File Type: PDF
Pages: 290 pages
File Size: 3,44 mb
   T Cell Activation by CD1 and Lipid Antigens (Current Topics in Microbiology and Immunology)

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The evolutionary history of CD1 is closely connected to the larger story of the evolution of the MHC. The MHC, in turn, has emerged as an important model for the more fundamental investigation of vertebrate genome evolution. Thus it is worth examining these broader topics to provide a conceptual framework for the evolution of CD1 [43]. Most of the theoretical models related to MHC evolution rely on known genetic mechanisms such as the expansion and contraction of gene families, duplication, deletion, neofunctionalization, chromosome translocation,andevenwhole genomeduplication (polyploidization).

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