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Science/Engineering Structure-based Drug Discovery

Posted on 2010-03-15




Name:Science/Engineering Structure-based Drug Discovery
ASIN/ISBN:1402044062
Language:English
File size:18 Mb
Publish Date: 2007-02-21
ISBN: 1402044062
Pages: 264 pages
File Type: PDF
File Size: 18 mb
Other Info: Springer
   Science/Engineering Structure-based Drug Discovery

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Harren Jhoti(Editor) Andrew Leach(Editor),"Structure-based Drug Discovery"

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as we as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

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Science/Engineering Structure-based Drug Discovery by Harren Jhoti

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