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Science/Engineering Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics (Biotechnology: Pharmaceutical Aspects) (Biotechnology: Pharmaceutical Aspects)

Posted on 2010-04-28

Name:	Science/Engineering Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics (Biotechnology: Pharmaceutical Aspects) (Biotechnology: Pharmaceutical Aspects)
ASIN/ISBN:	0387691499
Author:	Patrick Augustijns
Publisher:	Springer (2007)
Pages:	Hardcover, 472 pages
File size:	4.37 Mb

Science/Engineering Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics (Biotechnology: Pharmaceutical Aspects) (Biotechnology: Pharmaceutical Aspects)

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Author: Patrick Augustijns

Publisher: Springer (2007)

Binding: Hardcover, 472 pages

pricer: $189.00

ISBN-10: 0387691499

editorialreviews

Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.

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