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Sepsis: New Insights, New Therapies

Contents

Symposium on Sepsis: new insights, new therapies, held at the Novartis Foundation,

London, 14–16 February 2006

Editors: Derek J. Chadwick (Organizer) and Jamie Goode

This symposium was based on a proposal made by Mitchell Fink and Mervyn Singer

Mitchell P. Fink Chair’s introduction 1

Discussion 4

Alessandro Protti and Mervyn Singer Strategies to modulate cellular

energetic metabolism during sepsis 7

Discussion 16

Jérôme Pugin Immunostimulation is a rational therapeutic strategy in

sepsis 21

Discussion 27

Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl,

Joanne L. Lomas-Neira, Ryan Swan and Chun-Shiang Chung

Blockade of apoptosis as a rational therapeutic strategy for the treatment of

sepsis 37

Discussion 49

John C. Marshall, Zeenat Malam and Songhui Jia Modulating neutrophil

apoptosis 53

Discussion 67

Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey and

Andrew E. Sama HMGB1 as a potential therapeutic target 73

Discussion 85

Csaba Szabó Poly (ADP-ribose) polymerase activation and circulatory

shock 92

Discussion 103

Xavier Leverve, Cécile Batandier and Eric Fontaine Choosing the left

substrate 108

Discussion 121

Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A. Patel,

Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen,

Simon J. Foster, Muhammad M. Yaqoob and Christoph

Thiemermann Inhibiting glycogen synthase kinase 3β in sepsis 128

Discussion 142

Mitchell P. Fink Ethyl pyruvate: a novel treatment for sepsis 147

Discussion 156

General discussion I 160

Stefan W. Ryter and Augustine M. K. Choi Cytoprotective and

anti-infl ammatory actions of carbon monoxide in organ injury and sepsis

models 165

Discussion 175

Andrea Polito, Jérôme Aboab and Djillali Annane The hypothalamic

pituitary adrenal axis in sepsis 182

Discussion 199

Ilse Vanhorebeek, Lies Langouche and Greet Van den Berghe Modulating

the endocrine response in sepsis: insulin and blood glucose control 204

Discussion 215

Luis Ulloa and Ping Wang The neuronal strategy for infl ammation 223

Discussion 233

C. T. Pereira, M. G. Jeschke and D. N. Herndon Beta-blockade in

burns 238

Discussion 248

Mervyn Singer System interactions 252

Discussion 262

C. A. Piantadosi, M. S. Carraway, D. W. Haden and H. B. Suliman

Protecting the permeability pore and mitochondrial biogenesis 266

Discussion 276

Contributor index 281

Subject index 283

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