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This book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications. Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and ApplicationsDiscover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods.

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Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods.

The text's three sections highlight its interdisciplinary approach:

*Part One: Nanostructure Fabrication

*Part Two: Bio-Nano Interfaces

*Part Three: Clinical Applications of Nanostructures

Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication.

Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points.

In addition, references at the end of the chapter help you expand your research on any individual topic.

CONTENTS

Contributors

Part I. Nanostructure Fabrication

1 Nanofabrication Techniques - Joseph W. Freeman, Lee D. Wright, Cato T. Laurencin, and Subhabrata Bhattacharyya

2 Micro/Nanomachining and Fabrication of Materials for Biomedical Applications - Wei He, Kenneth E. Gonsalves, and Craig R. Halberstadt

3 Novel Nanostructures as Molecular Nanomotors - Yan Chen, Jianwei Jeff Li, Zehui Charles Cao, and Weihong Tan

4 Bioconjugation of Soft Nanomaterials - Neetu Singh, William H. Blackburn, and Andrew Lyon

5 Nanotechnology and Drug Delivery - Xiaojun Yu, Chandra M. Valmikinathan, Amanda Rogers, and Junping Wang

6 Polymeric Nanoparticles and Nanopore Membranes for Controlled Drug and Gene Delivery - Jingjiao Guan, Hongyan He, Bo Yu, and L. James Lee

7 Development of Nanostructures for Drug Delivery Applications - Nikhil Dube, Joydeep Dutta, and Dhirendra S. Katti

8 Bioconjugated Nanoparticles for Ultrasensitive Detection of Molecular Biomarkers and Infectious Agents - Amit Agrawal, May Dongmei Wang, and Shuming Nie

Part II. Bio-Nano Interfaces

9 ECM Interactions with Cells from the Macroto Nanoscale - Steve Mwenifumbo and Molly M. Stevens

10 Cell Behavior Toward Nanostructured Surfaces - Sangamesh G. Kumbar, Michelle D. Kofron, Lakshmi S. Nair, and Cato T. Laurencin

11 Cellular Behavior on Basement Membrane Inspired Topographically Patterned Synthetic Matrices - Joshua Z. Gasiorowski, John D. Foley, Paul Russell, Sara J. Liliensiek, Paul F. Nealey, and Christopher J. Murphy

12 Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function - Tanmay Lele and Donald E. Ingber

13 Controlling Cell Behavior via DNA and RNA Transfections - Jaspreet K. Vasir and Vinod Labhasetwar

14 Multiscale Coculture Models for Orthopedic Interface Tissue Engineering - Helen H. Lu and I-Ning E. Wang

Part III. Clinical Applications of Nanostructures

15 Nanostructures for Tissue Engineering/Regenerative Medicine - Syam P. Nukavarapu, Sangamesh G. Kumbar, Lakshmi S. Nair, and Cato T. Laurencin

16 Nanostructures for Cancer Diagnostics and Therapy - Kumerash S. Soppimath and Guru V. Betageri

17 Clinical Applications of Micro- and Nanoscale Biosensors - David W.G. Morrison, Mehmet R. Dokmeci, Utkan Demirci, and Ali Khademhosseini

18 Nanoscale Iron Compounds Related to Neurodegenerative Disorders - Joanna F. Collingwood and Jon Dobson

19 Application of Nanotechnology into Life Science: Benefit or Risk - Yoon-Sik Lee and Myung-Haing Cho

Acknowledgments

References

Index

with TOC BookMarkLinks

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