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Lectures on Numerical Methods in Bifurcation Problems
Methods for Finding Zeros in Polynomials
Lectures on Stochastic Flows and Applications
Educational Psychology by Edward L. Thorndike
The Last Days of Tolstoy by V. G. Chertkov
Globalization and Responsibility
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History of the Incas by Pedro Sarmiento de Gamboa
Linear Algebra: Theorems and Applications
Lectures on Stochastic Differential Equations and Malliavin Calculus
A Short Biographical Dictionary of English Literature
Lectures on Sieve Methods and Prime Number Theory
Dollars and Sense by William Crosbie Hunter
The Theory of the Theatre by Clayton Hamilton
The Mathematics of Investment
Occupiers of Wall Street: Losers or Game Changers
The Solution of the Pyramid Problem
Lectures on Moduli of Curves
Walden by Henry David Thoreau
Methods for Finding Zeros in Polynomials
Lectures on Stochastic Flows and Applications
Educational Psychology by Edward L. Thorndike
The Last Days of Tolstoy by V. G. Chertkov
Globalization and Responsibility
Lectures on Siegel Modular Forms and Representation by Quadratic Forms
Lectures on Topics In One-Parameter Bifurcation Problems
History of the Incas by Pedro Sarmiento de Gamboa
Linear Algebra: Theorems and Applications
Lectures on Stochastic Differential Equations and Malliavin Calculus
A Short Biographical Dictionary of English Literature
Lectures on Sieve Methods and Prime Number Theory
Dollars and Sense by William Crosbie Hunter
The Theory of the Theatre by Clayton Hamilton
The Mathematics of Investment
Occupiers of Wall Street: Losers or Game Changers
The Solution of the Pyramid Problem
Lectures on Moduli of Curves
Walden by Henry David Thoreau
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Pore-forming Peptides and Protein Toxins (Cell and Molecular Mechanisms of Toxin Action, Volume 5)
Posted on 2010-04-28
|
Author:
Publisher: CRC (2003) Binding: Hardcover, 360 pages pricer: $179.95 ISBN-10: 0415298520 editorialreviews Pore-forming proteins and peptides are ubiquitous in living organisms. They play a central role in bacterial pathogenesis, immune response, venomous attack and innate immunity, by which means they are used to attack and eliminate other organisms. They have the extraordinary property of having two stable structural states. One corresponds to the secreted, soluble, diffusible, and usually monomeric form. The other, adopted only upon cellular attack, is a membrane inserted, channel shaped, and usually oligomeric form. Since membrane insertion is self-assisted and does not require a chaperon or dedicated protein machinery, these molecules represent a gold mine for biochemists and biophysicists interested in the molecular steps leading to membrane insertion and channel formation. As self-assembling entities, capable of punching holes of well-defined size in a lipid membrane, they have found a wealth of applications ranging from cell controlled permeabilisation to intracellular drug delivery, and from the creation of chimeric antitumoral immunotoxins to the preparation of sophisticated elements for biosensors of metal ions or genetic material. Pore-forming Peptides and Protein Toxins provides an essential source of information for graduate students and academic and industrial researchers in the fields of biochemistry, biophysics, toxicology and the pharmaceutical sciences. checked
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