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Polymer Drugs in the Clinical Stage: Advantages and Prospects by Hiroshi Maeda (Repost)
Posted on 2010-06-11
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More Polymer Drugs in the Clinical Stage: Advantages and Prospects (Advances in Experimental Medicine and Biology) by Hiroshi Maeda (Repost) Progress in research on polymeric-drugs has been remarkable in the past few decades, whereas development of clinical applications of these drugs has been slow. The oldest and most widely used polymer-based drug is an antiseptic agent, povidone-iodine, which consists of a complex of poly (1- vinyl-2-pyrrolidone) and iodine. Used since the 1950s, it is still the best antiseptic agent available. True polymer-based drugs that can be administered by injection did not become practical until the 1990s, although the numbers of polymeric drugs such as SMANCS and interferon that are now being used in clinics is still limited. As will be apparent in this volume, however, the great potential of these drugs is now clear, especially in view of their prolonged plasma half-life and enhanced targeting to sites of either cancerous or inflammatory lesions. Use of these drugs will result in great benefits for patients in terms of compliance and quality of life, as well as improved therapeutic efficacy and cost effectiveness of the drugs. Realization of such advantages becomes a strong incentive for research scientists and entrepreneurs, and there are probably more than three-dozen candidate drugs with polymer conjugates currently under development.
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