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Pharmacogenetics. Opportunities and Challenges for Health Innovation

This book reviews the use of pharmacogenetics across all stages of the health innovation cycle from research through to uptake by doctors and patients. It focuses on how to optimise the use of pharmacogenetics to deliver effective innovations for public health, and design policies that enhance their economic and social benefits.

The book argues for large-scale studies to validate the biomarkers that underpin pharmacogenetics and policies to share the cost and risk of using pharmacogenetics to improve the use of existing medicines. Governments and others need to align regulatory, reimbursement and other incentives and work with industry to measure better the impacts of pharmacogenetics. Health systems need to take positive steps to adapt to the use of pharmacogenetics and ensure that health professionals receive adequate training.

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Pharmacogenetics helps us understand the relationship between an individual’s genetic make-up and the way medicines work for each person.

Table of Contents

Acronyms

Executive Summary

Introduction to the Policy issues

The Supporting Infrastructures for Pharmacogenetics

Pharmacogenetics and Drug Development

Business Models for Pharmacogenetics

Physician and Patient Demand for Pharmacogenetics

Regulatory Authorities and Reimbursement Mechanisms

Conclusions

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