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P. Sachdev - The Ageing Brain: The Neurobiology and Neuropsychiatry of Ageing

When confronted with a neurological or psychiatric in an elderly individual, a clinician or researcher is likely to ask how the processes of ageing have influenced the aetiology and presentation of the disorder, and will impact on its efficent management. There are many urban myths about ageing, and some of these apply to the brain. The reviews included in this book are an attempt to flush out these myths, and arm the clinician and general researcher with the empirical facts that can be mustered to substantiate claims about ageing. There are many salient questions: Is cognitive change to be expected in an elderly individual? Is this change progressive, relentless and unselective, or is it focal and constrained? Would every person who lived long enough develop Alzhiemer's disease? Do our neurones die as we grow old? What happens to the size of the brain and its metabolic activity? How do our hormones change with age? Can antioxidants slow or even stop the process of ageing? Are genes important for the ageing brain, or is it all in the environment? how much of what we are is due to what we eat? The contributors to this book, each an expert in his field, have addressed some of these questions in a language simple enough for a general reader to understand.

The book also deals with some of the most prominent brain disorders of old age - Alzheimer's disease, parkinson's disease, Vascular dementia and Depression. The focus is on the impact of ageing on these disorders. The discussion lay out a broad map for the clinician dealing with neuropsychiatric disorders, and the future researcher of brain ageing. In a field in which the developments are too numerous for any any one individual to keep pace with, this book presents up-to-date summmaries that can be a useful starting point. The field of brain ageing abounds in tabloid science. This book counters this by providing a strong empircial grounding and considered synthesis of the research.

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