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Technical Organic Synthesis on Solid Phase: Supports, Linkers, Reactions by Florencio Zaragoza Dörwald (Repost)
Posted on 2010-09-09
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More Organic Synthesis on Solid Phase: Supports, Linkers, Reactions by Florencio Zaragoza Dörwald (Repost) Although the concept of performing organic synthesis on insoluble supports is almost 40 years old, there has been rapid growth of this research area in recent years. It was probably the idea of 'parallel synthesis', proposed by several groups in the late 1980s, which spurred renewed interest in solid-phase chemistry. Parallel synthesis enables the rapid production of large numbers of compounds, and is therefore of criti- cal importance to all organizations which depend on discovering new, patentable sub- stances. In particular the implementation of robotic high-throughput screening, which enables the testing of thousands of compounds per day, has originated the need for comparably fast compound production. Solid-phase synthesis is well suited to perform reactions in parallel, because it readily enables the automated performance of multistep synthetic sequences. Accordingly, solid-phase synthesis is becoming an increasingly important tool for the synthetic chemist, as the trend towards automation and miniaturization of synthesis continues.
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