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Infrared Spectroscopy - Life and Biomedical Sciences
Medical Physiology - Principles for Clinical Medicine (4th edition)
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Medical Physiology - Principles for Clinical Medicine (4th edition)
Medical Physiology: Principles for Clinical Medicine (4th edition) [Repost]
Hypnosis: Medical, Scientific or Occultic? (repost)
Handbook of Antimicrobial Therapy by Medical Letter, Mark Abramowicz, M.D. and Gianna Zuccotti
Medical Management of the Thoracic Surgery Patient Expert Consult - Online and Print, 1e (Repost)
Achieving Excellence in Medical Education (2nd edition) [Repost]
Medical Dosage Calculations: A Dimensional Analysis Approach, 10th Edition (Repost)
A Guide to Methods in the Biomedical Sciences [Repost]
Medical Cirugia de Michans / Michan's Surgery (Spanish Edition)
Sherris Medical Microbiology, 5th Edition
Your Medical Mind: How to Decide What Is Right for You (Repost)
For Dummies Series PDF - [ Medical ]
Medical e-Books Megapack English
Mechanical Circulatory Support (Landes Bioscience Medical Handbook (Vademecum)) by Wayne E. Richenbacher (Repost)
Analyzing the Large Number of Variables in Biomedical and Satellite Imagery (Repost)
How to Study in Medical School
Biomedical Simulation (repost)
Polyphosphazenes for Biomedical Applications by A. K. Andrianov (Repost)
Costanza Medical Physiology Video Lectures
Useful Links
Medical Multifunctional Pharmaceutical Nanocarriers
Posted on 2010-10-29
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The use of various pharmaceutical carriers to enhance the in vivo efficiency of many drugs and drug administration protocols has been well established during the last decade in both pharmaceutical research and clinical setting. Surface modification of pharmaceutical nanocarriers, such as liposome, micelles, nanocapsules, polymeric nanoparticles, solid lipid particles, and niosomes, is normally used to control their biological properties in a desirable fashion and to simultaneously make them perform various therapeutically or diagnostically important functions. The most important results of such modification include an increased stability and half-life of drug carriers in the circulation, required biodistribution, passive or active targeting into the required pathological zone, responsiveness to local physiological stimuli, and ability to serve as contrast agents for various imaging modalities (gamma-scintigraphy, magnetic resonance imaging, computed tomography, ultra-sonography). Frequent surface modifiers (used separately or simultaneously) include soluble synthetic polymers (to achieve carrier longevity); specific ligands, such as antibodies, peptides, folate, transferrin, and sugar moieties (to achieve targeting effect); pH- or temperature-sensitive lipids or polymers (to impart stimuli sensitivity); chelating compounds, such as EDTA, DTPA, and deferoxamine (to add a heavy metal-based diagnostic/contrast moiety onto a drug carrier).
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