Book123

    Free register and download UseNet downloader, then you can FREE Download from UseNet.

    Download without Limit " Science/Engineering Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease " from UseNet for FREE!

More

Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease (Advances in Experimental Medicine and Biology)

Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoetic system and function to transduce signals leading to a variety of biologic responses. These receptors share common structural features, including extracellular ligand-binding domains and intracellular signaling domains carried on separate subunits. Another important feature linking members of the MIRR family is the presence of one or more copies of a cytoplasmic structural module termed the immunoreceptor tyrosine-based activation motif (ITAM). ITAMs consist of conserved sequences of amino acids that contain two appropriately spaced tyrosines (YxxL/Ix6–8YxxL/I; where x denotes non-conserved residues). Following receptor engagement, phosphorylation of ITAM tyrosine residues represents one of the earliest events in the signaling cascade. Although the MIRR-mediated ligand-recognition and the MIRR-triggered signaling cascades are believed to be among the best-studied in biology in recent years, at present the spatial organization of the MIRRs, its reorganization in response to ligand binding as well as the molecular mechanisms underlying the initiation of MIRR signaling remain to be elucidated.

The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and furthermore, provides the basis for existing and future therapeutic strategies targeting MIRRs. This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualize cell-cell interaction contacts such as immunological synapse and to measure protein-protein interactions in space in real time. Potential therapeutic strategies targeting the MIRR-mediated transmembrane signal transduction will be shortly reviewed in Section 3. This book will summarize our current knowledge in this field and illustrate how control of the MIRR-triggered signaling could become a potential target of medical intervention, thus bridging basic and clinical immunology. Describing the molecular basis of MIRR-mediated transmembrane signaling, this volume will address a broad audience ranging from biochemists and immunologists and to molecular biologists and to pharmacologists.

Buy Book at Lowest Price on Amazon

Download - (25 Mb)

Mirror

Rating:
2.5 out of 5 by Book123