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Medical Physiology - Principles for Clinical Medicine (4th edition)
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Medical Molecular Neurosurgery with Targeted Toxins
Posted on 2010-03-15
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Molecular Neurosurgery with Targeted Toxins
By Ronald G. Wiley (Editor), Douglas A. Lappi (Editor) Publisher: Humana Press Number Of Pages: 328 Publication Date: 2005-03-22 Sales Rank: 2380283 ISBN / ASIN: 1588291995 EAN: 9781588291998 Binding: Hardcover Manufacturer: Humana Press Studio: Humana Press Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.pass: gigapedia.org
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