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Molecular Genetics of Recombination by: Andrés Aguilera (Editor), Rodney Rothstein (Editor)

Posted on 2010-04-14




Name:Molecular Genetics of Recombination by: Andrés Aguilera (Editor), Rodney Rothstein (Editor)
ASIN/ISBN:3540710205
Publisher:Springer
Publish Date:2007
Pages:510 pages
File size:17.6 Mb
Publisher: Springer
Publish Date: 2007
ISBN: 3540710205
Pages: 510 pages
File Size: 17.6 Mb
   Molecular Genetics of Recombination by: Andrés Aguilera (Editor), Rodney Rothstein (Editor)

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Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge.

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