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Colleen Smith, Allan Marks, Michael A Lieberman, "Marks' Basic Medical Biochemistry: A Clinical Approach"

An excellent clinically based medical biochemistry book. Good examples of realistic cases.

This best-selling resource utilizes a comprehensive yet practical approach that students understand. The authors present facts and pathways to emphasize how the underlying biochemistry is related to the body's overall physiological functions. Detailed case studies show students the relationship between biochemistry and clinical problems. The Second Edition has been heavily revised with completely updated illustrations while maintaining the unique, patient-oriented approach that made the original so popular. A new CD-ROM in the back of the book features chapter-by-chapter test questions, detailed 3-D representations of enzyme structure, PowerPoint slides, and real patient stories.

Table of Contents

1 Metabolic fuels and dietary components 3

2 The fed or absorptive state 22

3 Fasting 30

4 Water, acids, bases, and buffers 41

5 Structures of the major compounds of the body 54

6 Amino acids in proteins 72

7 Structure-function relationships in proteins 92

8 Enzymes as catalysts 115

9 Regulation of enzymes 138

10 Relationship between cell biology and biochemistry 157

11 Cell signaling by chemical messengers 184

12 Structure of the nucleic acids 207

13 Synthesis of DNA 222

14 Transcription : synthesis of RNA 237

15 Translation : synthesis of proteins 258

16 Regulation of gene expression 274

17 Use of recombinant DNA techniques in medicine 297

18 The molecular biology of cancer 317

19 Cellular bioenergetics : ATP and O[subscript 2] 341

20 Tricarboxylic acid cycle 360

21 Oxidative phosphorylation and mitochondrial function 380

22 Generation of ATP from glucose : glycolysis 399

23 Oxidation of fatty acids and ketone bodies 418

24 Oxygen toxicity and free radical injury 439

25 Metabolism of ethanol 458

26 Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones 477

27 Digestion, absorption, and transport of carbohydrates 493

28 Formation and degradation of glycogen 511

29 Pathways of sugar metabolism : pentose phosphate pathway, fructose, and galactose metabolism 527

30 Synthesis of glycosides, lactose, glycoproteins, and glycolipids 542

31 Gluconeogenesis and maintenance of blood glucose levels 556

32 Digestion and transport of dietary lipids 583

33 Synthesis of fatty acids, triacylglycerols, and the major membrane lipids 594

34 Cholesterol absorption, synthesis, metabolism, and fate 619

35 Metabolism of the eicosanoids 654

36 Integration of carbohydrate and lipid metabolism 668

37 Protein digestion and amino acid absorption 687

38 Fate of amino acid nitrogen : urea cycle 697

39 Synthesis and degradation of amino acids 712

40 Tetrahydrofolate, vitamin B12, and S-adenosylmethionine 732

41 Purine and pyrimidine metabolism 747

42 Intertissue relationships in the metabolism of amino acids 762

43 Actions of hormones that regulate fuel metabolism 783

44 The biochemistry of the erythrocyte and other blood cells 805

45 Blood plasma proteins, coagulation, and fibrinolysis 827

46 Liver metabolism 842

47 Metabolism of muscle at rest and during exercise 862

48 Metabolism of the nervous system 881

49 The extracelluar matrix and connective tissue 905

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