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Science/Engineering Lyme Borreliosis: Biological and Clinical Aspects (2009)

Posted on 2010-03-16




Name:Science/Engineering Lyme Borreliosis: Biological and Clinical Aspects (2009)
ASIN/ISBN:3805591144
Language:English
File size:4 Mb
Publisher: S. Karger AG
Language: English
ISBN: 3805591144
Pages: 212 pages
Publish Date: 2009
File Type: PDF
File Size: 4 Mb
   Science/Engineering Lyme Borreliosis: Biological and Clinical Aspects (2009)

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Lyme Borreliosis: Biological and Clinical Aspects

Description: ‘Lyme disease’, so called since Steere et al. [1, 2] inquired into an arthritis epidemic

among young children in the community of Old Lyme, Conn., USA, in the late 1970s,

has a very long European history. Its cutaneous manifestations, the most frequent

signs of the disease, had already been described at the end of the 19th century and the

beginning of the 20th century by physicians like Buchwald, Pick, Herxheimer, Hartman,

Afzelius and Lipschutz [3–5] . Additionally, two French physicians in a landmark

paper published in 1922, Garin and Bujadoux [6] , reported a patient who developed

erythema chronicum migrans followed by painful meningoradiculitis. Shortly

before the symptoms began, this patient was bitten by a tick and he had a positive

Bordet-Wasserman test, which was used at this time to diagnose syphilis. They stated,

however, that although this test was positive, this patient did not have syphilis, and

concluded that this patient had a tick-borne disease that induced cutaneous and neurological

manifestations caused by a spirochete different from Treponema pallidum .

It was not until the early 1980s that their prediction proved to be correct, when Burgdorfer

et al. [7] were able to isolate a bacterium belonging to the family of Spirochaetaceae,

first from ticks and then from humans. Interestingly, the first North American

observation of Lyme disease, a patient with erythema migrans, was only published

in 1970 [8]

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