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Lloyd R. Snyder, Joseph J. Kirkland, John W. Dolan, "Introduction to Modern Liquid Chromatography, Third Edition"

The latest edition of the authoritative reference to HPLC

High-performance liquid chromatography (HPLC) is today the leading technique for chemical analysis and related applications, with an ability to separate, analyze, and/or purify virtually any sample. Snyder and Kirkland's Introduction to Modern Liquid Chromatography has long represented the premier reference to HPLC. This Third Edition, with John Dolan as added coauthor, addresses important improvements in columns and equipment, as well as major advances in our understanding of HPLC separation, our ability to solve problems that were troublesome in the past, and the application of HPLC for new kinds of samples.

This carefully considered Third Edition maintains the strengths of the previous edition while significantly modifying its organization in light of recent research and experience. The text begins by introducing the reader to HPLC, its use in relation to other modern separation techniques, and its history, then leads into such specific topics as:

The basis of HPLC separation and the general effects of different experimental conditions

Equipment and detection

The column—the "heart" of the HPLC system

Reversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniques

Computer simulation, qualitative and quantitative analysis, and method validation and quality control

The separation of large molecules, including both biological and synthetic polymers

Chiral separations, preparative separations, and sample preparation

Systematic development of HPLC separations—new to this edition

Troubleshooting tricks, techniques, and case studies for both equipment and chromatograms

Designed to fulfill the needs of the full range of HPLC users, from novices to experts, Introduction to Modern Liquid Chromatography, Third Edition offers the most up-to-date, comprehensive, and accessible survey of HPLC methods and applications available.

Summary: They never dissapoint

Rating: 5

I have an older edition of this book, and I bought this one primarily because I was using it as a reference in a paper and wanted the most up to date version. I thought: how different could it be? Answer: I've already changed some techniques, ideas as a result of what I've read.

Pros: well organized

clearly written

very informative-lots of information for anyone new to chromatography, and for experienced chromatographers

I love these guys!

Summary: The Bible for the Chromatographer

Rating: 5

Introduction to Modern Liquid Chromatography - This book is a must for anyone practicing liquid chromatography. It is a great resource for both the novice and experienced chemist. Highly recommended.

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