Medical Integrated Drug Discovery Technologies (0824706498)

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Integrated Drug Discovery Technologies

edited by Houng-Yau Mei and Anthony W. Czarnik

577pages |pdf |size: 6,9 Mb

As the first of its kind, this up-to-the-minute reference provides a global overview of emerging drug discovery technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences.

Combining integration of contemporary mechanization with strategies in drug discovery, this volume features the most current advances that will afford better, faster, and more cost-effective means of design and screening.

To make the most of current and developing methods, Integrated Drug Discovery Technologies

& 8226; presents the most promising science with the potential to revolutionize the drug discovery process

& 8226; explains the rationale and developmental background behind evolving practices

& 8226; highlights the impact of Information Technology on drug discovery

& 8226; details information management, including strategies and infrastructure

With over 40 world-renowned experts, Integrated Drug Discovery Technologies is an invaluable resource for organic, analytical, medicinal, pharmaceutical, computational, protein, and peptide chemists and biochemists; pharmacists; pharmacologists; molecular and cell biologists; and upper-level undergraduate and graduate students in these disciplines.

Contents

Introduction

1. The Motivation: A Top-Down View

Part I: from Gene to Screen

2. Target Identification and Validation: Coupling Genotype to Phenotype

3. Functional Genomics

4. Integrated Proteomics Technologies

5. where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications

6. SNP Scoring for Drug Discovery Applications

7. Protein Display Chips

8. Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets

Part II: High-Throughput Screening

9. High-Throughput Screening as a Discovery Resource

10. Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS+ plus): Multiple Read-Out Options for Miniaturized Screening

11. Homogeneous Time-Resolved Fluorescence

12. ADME-Tox Screening in Drug Discovery

13. Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells

14. Miniaturization Technologies for High-Throughput Biology

15. Data Management for High-Throughput Screening

Part III: High-Throughput Chemistry

16. Combinatorial Chemistry: The History and the Basics

17. New Synthetic Methodologies

18. Supports for Solid-Phase Synthesis

19. The NMR "Toolkit" for Compound Characterization

20. Materials Management

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	Medical Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (Wiley Series in Drug Discovery Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (Wiley Series in Drug Discovery and Development) Publisher: Wiley-InterscienceNumber Of Pages: Publication Date: 2007-06-29Sales Rank: 2586696ISBN / ASIN: 0471743 ...
	Science/Engineering Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (Wiley Series in Drug Discovery and Development) Publisher: Wiley-InterscienceLanguage: englishISBN: 047174302XPaperback: 320 pagesData: June 29, 2007Format: PDFDescription: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have be ...
	Science/Engineering Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools Sean Ekins, Jinghai J. Xu, "Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools (Wiley Series on Technologies for the Pharmaceutical Industry)"Wiley \| 2009-01-14 \| ISBN: 0470225556 \| 408 pages \| PDF \| 44,2 MBThis ...
	Study Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1) (ReUp) Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1) Wiley-Interscience (January 17, 2003) \| ISBN-10: 0471270903 \| 960 pages \| PDF \| 47,1 MB "An essential addition to the libraries of any medicinal chemist . . . an o ...
	Study Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2) (ReUp) Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2) Wiley-Interscience (January 23, 2003) \| ISBN-10: 0471370282 \| 832 pages \| PDF \| 37,6 MB "An essential addition to the libraries of any medicin ...
	Science/Engineering Protein Discovery Technologies (Drug Discovery Series) Protein Discovery Technologies (Drug Discovery Series)CRC \| ISBN: 0824754689 \| 2009-07-28 \| PDF \| 250 pages \| 3 Mb A True Insider’s Guide to the Field – Then and NowUntil now, there has not been a book that effectively addresses the histo ...

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	Medical Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (Wiley Series in Drug Discovery Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (Wiley Series in Drug Discovery and Development) Publisher: Wiley-InterscienceNumber Of Pages: Publication Date: 2007-06-29Sales Rank: 2586696ISBN / ASIN: 0471743 ...
	Science/Engineering Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (Wiley Series in Drug Discovery and Development) Publisher: Wiley-InterscienceLanguage: englishISBN: 047174302XPaperback: 320 pagesData: June 29, 2007Format: PDFDescription: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have be ...
	Science/Engineering Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools Sean Ekins, Jinghai J. Xu, "Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools (Wiley Series on Technologies for the Pharmaceutical Industry)"Wiley \| 2009-01-14 \| ISBN: 0470225556 \| 408 pages \| PDF \| 44,2 MBThis ...
	Study Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1) (ReUp) Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1) Wiley-Interscience (January 17, 2003) \| ISBN-10: 0471270903 \| 960 pages \| PDF \| 47,1 MB "An essential addition to the libraries of any medicinal chemist . . . an o ...
	Study Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2) (ReUp) Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2) Wiley-Interscience (January 23, 2003) \| ISBN-10: 0471370282 \| 832 pages \| PDF \| 37,6 MB "An essential addition to the libraries of any medicin ...
	Science/Engineering Protein Discovery Technologies (Drug Discovery Series) Protein Discovery Technologies (Drug Discovery Series)CRC \| ISBN: 0824754689 \| 2009-07-28 \| PDF \| 250 pages \| 3 Mb A True Insider’s Guide to the Field – Then and NowUntil now, there has not been a book that effectively addresses the histo ...

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