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The AIDS pandemic has had a remarkable course during the more than

quarter century since it was first detected. Tens of millions of individuals

have died because the complications of HIV infection, and at present more

than 40 million people across the planet are living with HIV. As of next

year, it is expected that there will be an additional 3 million deaths and

probably 5 million new infections. Nonetheless, the past few years have seen

remarkable advances in antiretroviral chemotherapy. Highly active antiretroviral

therapy has resulted in the ability of many people living with HIV

to lead highly productive lives, with pill burdens as low as one pill taken

once a day and with minimal side effects. Not everyone living with HIV

who has access to therapy has an uncomplicated course, and there are concerns

about chronic, metabolic, immunologic effects of the therapies themselves

as well as concerns about the effects of chronic HIV infection. At the

same time, the ultimate moral imperative is to avoid unnecessary deaths and

morbidity by making the benefits of antiretroviral therapy available to the

largest number of people throughout the world as soon as possible.

Global Epidemiology of HIV-AIDS

Diagnosis and Management of Acute HIV Infection

Primary Care Issues for HIV-Infected Patients

Antiretroviral Management of Treatment-Naive Patients

Approach to the Treatment-Experienced Patient

Management of Antiretroviral TreatmentCRelated Complications

Special Care Issues of Women Living with HIV-AIDS

Clinical Care of the HIV-Infected Drug User

Behavioral Aspects of HIV Care: Adherence, Depression, Substance Use, and HIV-Transmission Behaviors

HIV Vaccine Efficacy Trials: Towards the Future of HIV Prevention

The Future of HIV Prevention: Prospects for an Effective Anti-HIV Microbicide

The Future of HIV Prevention: Control of Sexually Transmitted Infections and Circumcision Interventions

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