Science/Engineering History of Research on Tumor Angiogenesis (1402095597)

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History of Research on Tumor Angiogenesis

In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis.

Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy.

This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

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	Medical Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) Publisher: S. Karger AG (Switzerland)Number Of Pages: 168Publication Date: 2007-02-28Sales Rank: ISBN / ASIN: 3805582463EAN: 9783805582469Binding: Har ...
	Science/Engineering Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) by Kurt S. Zanker Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) by Kurt S. Zanker and Frank EntschladenPublisher: S. Karger AG \| February 28, 2007 \| ISBN: 3805582463 \| Pages: 167 \| PDF \| 4.96 MBShowing how tumors interact with t ...
	Science/Engineering Tumor Prevention and Genetics III (Recent Results in Cancer Research) (v. 3) H.-J. Senn, R. Morant, "Tumor Prevention and Genetics III (Recent Results in Cancer Research) (v. 3)"Publisher: Springer \| 2004-12-22 \| 334 Pages \| ISBN: 3540222286 \| PDF \| 9.3 MBThis volume contains the majority of the invited keynote lect ...
	Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy By Dieter Marmé, Norbert Fusenig Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy By Dieter Marmé, Norbert FusenigPublisher: Springer \| 2007-12-06 \| ISBN: 354033176X \| Pages: 845 \| PDF \| 17.9 MBTumor angiogenesis is one of the most prominent mechanisms driving tumo ...
	Technical Angiogenesis Inhibition (Recent Results in Cancer Research) Angiogenesis Inhibition (Recent Results in Cancer Research)Springer \| 2009-11-18 \| ISBN: 354078280X \| 231 pages \| PDF \| 2 MBAngiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and tar ...
	Technical Tumor Angiogenesis and Microcirculation Tumor Angiogenesis and MicrocirculationPublisher: Informa HealthCare \| ISBN: 0824702646 \| edition 2001 \| PDF \| 648 pages \| 3,49 mb Univ. Medical Center Utrecht, The Netherlands. Provides readers with a well-balanced overview of the current ...

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	Medical Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) Publisher: S. Karger AG (Switzerland)Number Of Pages: 168Publication Date: 2007-02-28Sales Rank: ISBN / ASIN: 3805582463EAN: 9783805582469Binding: Har ...
	Science/Engineering Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) by Kurt S. Zanker Neuronal Activity in Tumor Tissue (Progress in Experimental Tumor Research) by Kurt S. Zanker and Frank EntschladenPublisher: S. Karger AG \| February 28, 2007 \| ISBN: 3805582463 \| Pages: 167 \| PDF \| 4.96 MBShowing how tumors interact with t ...
	Science/Engineering Tumor Prevention and Genetics III (Recent Results in Cancer Research) (v. 3) H.-J. Senn, R. Morant, "Tumor Prevention and Genetics III (Recent Results in Cancer Research) (v. 3)"Publisher: Springer \| 2004-12-22 \| 334 Pages \| ISBN: 3540222286 \| PDF \| 9.3 MBThis volume contains the majority of the invited keynote lect ...
	Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy By Dieter Marmé, Norbert Fusenig Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy By Dieter Marmé, Norbert FusenigPublisher: Springer \| 2007-12-06 \| ISBN: 354033176X \| Pages: 845 \| PDF \| 17.9 MBTumor angiogenesis is one of the most prominent mechanisms driving tumo ...
	Technical Angiogenesis Inhibition (Recent Results in Cancer Research) Angiogenesis Inhibition (Recent Results in Cancer Research)Springer \| 2009-11-18 \| ISBN: 354078280X \| 231 pages \| PDF \| 2 MBAngiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and tar ...
	Technical Tumor Angiogenesis and Microcirculation Tumor Angiogenesis and MicrocirculationPublisher: Informa HealthCare \| ISBN: 0824702646 \| edition 2001 \| PDF \| 648 pages \| 3,49 mb Univ. Medical Center Utrecht, The Netherlands. Provides readers with a well-balanced overview of the current ...

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