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Science/Engineering Engineering the Knee Meniscus (Synthesis Lectures on Tissue Engineering)

Posted on 2010-03-16




Name:Science/Engineering Engineering the Knee Meniscus (Synthesis Lectures on Tissue Engineering)
ASIN/ISBN:1598298720
Language:English
File size:5.8 Mb
Publisher: Morgan & Claypool Publishers
Publish Date: 2009
ISBN: 1598298720
Pages: 120 pages
File Type: PDF
File Size: 5,8 MB
   Science/Engineering Engineering the Knee Meniscus (Synthesis Lectures on Tissue Engineering)

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Kyriacos Athanasiou, Johanna Sanchez-adams, "Engineering the Knee Meniscus (Synthesis Lectures on Tissue Engineering)"

ABSTRACT

The knee meniscus was once thought to be a vestigial tissue, but is now known to be instrumental

in imparting stability, shock absorption, load transmission, and stress distribution within the knee

joint. Unfortunately,most damage to the meniscus cannot be effectively healed by the body. Meniscus

tissue engineering offers a possible solution to this problem by striving to create replacement tissue

that may be implanted into a defect site.With a strong focus on structure-function relationships,

this book details the essential anatomical, biochemical, and mechanical aspects of this versatile tissue

and reviews current meniscus tissue engineering strategies and repair techniques.We have written

this text such that undergraduate students, graduate students, and researchers will find it useful as

a first foray into tissue engineering, a cohesive study of the meniscus, or a reference for meniscus

engineering specifications.

PREFACE:

The inspiration for writing this monograph came from our desire to highlight important

aspects of the knee meniscus as they relate to tissue engineering and outline historical and current

advances in the field. Our goal was to create a cohesive, logical, and graphic work that guides

the reader through a study of the meniscus through the eyes of a tissue engineer. We hope that

undergraduate students, graduate students, and researchers alike will find this information useful as

an introductory guide to engineering the meniscus or a reference for future engineering attempts.

The first half of the monograph focuses on native characteristics of the knee meniscus including

its biochemical makeup, mechanical properties, and the limited ability of the tissue to self-repair.

The second half reviews tissue engineering attempts aimed at recreating meniscus biochemistry and

mechanics to repair damaged tissue, and highlights important considerations for meniscus tissue

engineers. Throughout the chapters particular emphasis is placed on the functional aspect of the

meniscus and its importance in a tissue engineered construct. We hope that the overall outline

of this book allows the reader to understand the complexity of the knee meniscus and the need

for engineered meniscus tissue, while providing enough background to evaluate recent engineering

attempts. By documenting the field of meniscus engineering in this way, we aim to educate and

inspire innovation from current and future researchers.

Kyriacos A. Athanasiou and Johannah Sanchez-Adams

Rice University

March 2009

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