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Drug Metabolism and Transport: Molecular Methods and Mechanisms

Posted on 2010-03-16




Name:Drug Metabolism and Transport: Molecular Methods and Mechanisms
ASIN/ISBN:1588293246
Language:English
File size:6.55 Mb
Publisher: Humana Press
ISBN: 1588293246
Publish Date: edition 2004
File Type: PDF
Pages: 400 pages
File Size: 6,55 mb
   Drug Metabolism and Transport: Molecular Methods and Mechanisms

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A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

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