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Drug-Induced Liver Disease by Neil Kaplowitz and Laurie D. DeLeve

Books and articles entitled Drug-Induced Liver Disease have always held promise but ultimately disappointed, since they have never delivered a plausible account of the mechanisms involved. So why should this 700-page, beautifully presented book be any better? Our understanding of the mechanisms of how drugs cause liver disease has advanced enormously, and the past decade has seen an explosion of new information concerning the immunology, toxicology, and pharmacology of liver disease. Simultaneously, there has been a substantial increase in the number of drugs on the market, with the result that drugs are now the most common cause of acute liver failure, accounting for up to half of cases. Clinically, there are still diagnostic and therapeutic challenges, and diagnoses are more often based on "implication" than on certainty. It is therefore fitting that this book should appear now. It is authoritative, with contributions by experts in basic sciences as well as by clinical hepatologists. The first part of the book deals with mechanisms and the roles of cytochrome P-450, antioxidants, cytokines, and growth factors in hepatic regeneration, repair, and fibrosis. No book on liver disease can be complete without a discussion of the mechanisms of cell death, and here the current knowledge of apoptosis has provided much-needed insight into the induction of cell death by drugs. The roles of membrane transport and hepatotoxicity due to mitochondrial injury are also discussed.

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