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Science/Engineering Design and Analysis of Vaccine Studies

Posted on 2010-03-16




Name:Science/Engineering Design and Analysis of Vaccine Studies
ASIN/ISBN:0387403132
Language:English
File size:7 Mb
Publisher: Springer
Pages: 389
Publish Date: 2009-11-18
ISBN: 0387403132
File Type: PDF
File Size: 7 MB
   Science/Engineering Design and Analysis of Vaccine Studies

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Design and Analysis of Vaccine Studies

Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at the individual and at the population level. The book covers many different vaccine effects, including vaccine efficacy for susceptibility, for disease, for post-infection outcomes, and for infectiousness. The book includes methods for evaluating indirect, total and overall effects of vaccination programs in populations. Topics include household studies, evaluating correlates of immune protection, and applications of casual inference. Material on concepts of infectious disease epidemiology, transmission models, casual inference, and vaccines provides background for the reader. This is the first book to present vaccine evaluation in this comprehensive conceptual framework.

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