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Programming Computational Genetics and Genomics: Tools for Understanding Disease

Posted on 2010-03-15




Name:Programming Computational Genetics and Genomics: Tools for Understanding Disease
ASIN/ISBN:1588291871
Language:English
File size:2.2 Mb
ISBN: 1588291871
Publish Date: 1 edition (April 25, 2005)
Pages: 320 pages
File Type: PDF
File Size: 2.2 Mb
Other Info: Humana Press
   Programming Computational Genetics and Genomics: Tools for Understanding Disease

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Gary Peltz, ?Computational Genetics and Genomics: Tools for Understanding Disease?

Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases. They also describe how genetic analysis of human populations has yielded information on the genetic basis for susceptibility to asthma and other inflammatory diseases.

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