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Lectures on Numerical Methods in Bifurcation Problems
Methods for Finding Zeros in Polynomials
Lectures on Stochastic Flows and Applications
Educational Psychology by Edward L. Thorndike
The Last Days of Tolstoy by V. G. Chertkov
Globalization and Responsibility
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Lectures on Topics In One-Parameter Bifurcation Problems
History of the Incas by Pedro Sarmiento de Gamboa
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A Short Biographical Dictionary of English Literature
Lectures on Sieve Methods and Prime Number Theory
Dollars and Sense by William Crosbie Hunter
The Theory of the Theatre by Clayton Hamilton
The Mathematics of Investment
Occupiers of Wall Street: Losers or Game Changers
The Solution of the Pyramid Problem
Lectures on Moduli of Curves
Walden by Henry David Thoreau
Methods for Finding Zeros in Polynomials
Lectures on Stochastic Flows and Applications
Educational Psychology by Edward L. Thorndike
The Last Days of Tolstoy by V. G. Chertkov
Globalization and Responsibility
Lectures on Siegel Modular Forms and Representation by Quadratic Forms
Lectures on Topics In One-Parameter Bifurcation Problems
History of the Incas by Pedro Sarmiento de Gamboa
Linear Algebra: Theorems and Applications
Lectures on Stochastic Differential Equations and Malliavin Calculus
A Short Biographical Dictionary of English Literature
Lectures on Sieve Methods and Prime Number Theory
Dollars and Sense by William Crosbie Hunter
The Theory of the Theatre by Clayton Hamilton
The Mathematics of Investment
Occupiers of Wall Street: Losers or Game Changers
The Solution of the Pyramid Problem
Lectures on Moduli of Curves
Walden by Henry David Thoreau
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Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug by Bernhard Lippert
Posted on 2010-09-20
|
More Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Since Rosenberg’s serendipitous discovery of its antitumor activity, cisplatin has become one of the greatest success stories of cancer chemotherapy. The biomedical applications of this inorganic compound have had an enormous impact on the development of coordination chemistry, and have served to underline the critical importance of basic research. This book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis. In Part 1, Rosenberg describes in a very personal manner the history of cisplatin from its accidental discovery to its establishment as a leading cancer drug. In Part 2 is described the current clinical status of platinum-derived antitumor agents. The biochemistry of cisplatin and current views of its mode of action comprise Part 3, while Part 4 focuses on the chemistry relevant to interactions of platinum(II) species with biomolecules. The examples compiled in Part 5 elucidate the impact of cisplatin on specific fields within inorganic chemistry, from the ‘platinum blues’ to platinum(III) compounds. The book concludes with Part 6, a description of several new developments in the field, e.g., orally active platinum drugs and the screening of combinatorial libraries of platinum compounds for antitumor activity. This volume provides all scientists, from coordination chemists to oncologists, with a unique resource detailing the state-of-the-art and future research perspectives, together with the fascinating story, of cisplatin.
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