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Chirality in Drug Design and Development
Posted on 2010-04-14
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More edited by Indira K. Reddy and Reza Mehvar ISBN: 0824750624 | 2004 | English Covering every essential element in the development of chiral products, provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals�supporting researchers as they critically evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds. Contents • Effects of Crystal Structure and Physical Properties on the Release of Chiral Drugs • Use of Chiral Excipients in Formulations Containing Chiral Drugs • Transport of Chiral Molecules Across the Skin • Stereoselective Drug Delivery through Prodrug Approach • Stereoselectivity in Drug Action and Disposition: An Overview • Stereoselectivity in Pharmacokinetics and Pharmacodynamics: Selected Classes of Drugs • Stereospecific Pharmacokinetics and Pharmacodynamics: Cardiovascular Drugs • Chiral Inversion • Bioequivalency Determination of Racemic Drug Formulations: Is Stereospecific Assay Essential? • Regulatory Considerations in Drug Development of Stereoisomers Link: http://rapidshare.de/files/36775857/CiDDaD.rar ...
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