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Publisher: CRC (2002)

Binding: Hardcover, 424 pages

pricer: $189.95

ISBN-10: 0849311411

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One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a far off goal. Hence, the discovery that peptides derived from the HIV Tat protein and homeodomain of the Antennapedia transcription factor (penetratin) can translocate across the plasma membrane of live cells has opened up exciting new possibilities in biomedical research.This book fills the need for a comprehensive update of the research concerning these specialized peptides, called cell-penetrating peptides (CPPs), to which the drug molecule can attach and pass through the cell membrane. Divided into three parts, Cell-Penetrating Peptides: Processes and Applications covers classes of cell-penetrating peptides; mechanisms of cell penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid models; and applications of cell-penetrating peptides. These divisions cover all information from basic biochemistry to clinical application, including a clear description of the general rules for cellular uptake of the transport peptides. The overview of work in this area will lead to better designed novel transport peptides to achieve the more successful application of CPPs in research and therapy.

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	Science/Engineering Peptides: Synthesis, Structures, and Applications Peptides: Synthesis, Structures, and ApplicationsAcademic Press \| ISBN: 0123109205 \| 1995-10-19 \| PDF \| 511 pages \| 31 Mb In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active r ...
	Science/Engineering Ground Penetrating Radar Theory and Applications (ReUp) Harry M. Jol, "Ground Penetrating Radar Theory and Applications" Elsevier Science 2009 \| ISBN-10: 0444533486 \| 544 Pages \| PDF \| 12,4 MB Ground-penetrating radar (GPR) is a rapidly developing field that has seen tremendous progress over th ...
	Methods in Cell Biology, Volume 38: Cell Biological Applications of Confocal Microscopy Methods in Cell Biology, Volume 38: Cell Biological Applications of Confocal MicroscopyPublisher: Academic Press \| ISBN: 0125641380 \| edition 1993 \| PDF \| 380 pages \| 22 mb This volume of the acclaimed Methods in Cell Biology series provide ...
	Technical Cell Biological Applications of Confocal Microscopy, Volume 70, Second Edition (Methods in Cell Biology, 70) ISBN: 0125804458 Publisher: Academic Press Author: Description:Confocal Microscopy contains integrated and up-to-date coverage on the many various techniques and uses of the confocal microscope (CM). Techniques are described completely so t ...
	Technical Handbook of Cell-Penetrating Peptides Handbook of Cell-Penetrating Peptides Publisher: CRC \| ISBN: 0849350905 \| edition 2006 \| PDF \| 600 pages \| 5,45 mbIn this second edition, the authors summarize the current state of the field including recent reevaluations of earlier studie ...
	Technical Cell-Penetrating Peptides: Processes and Applications Cell-Penetrating Peptides: Processes and ApplicationsPublisher: CRC \| ISBN: 0849311411 \| edition 2002 \| PDF \| 424 pages \| 3,22 mbOne of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through th ...

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