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Health Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done (Current Clin
Posted on 2010-03-15
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Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done (Current Clinical Oncology) Publisher: Humana Press
Number Of Pages: 408 Publication Date: 2003-11-24 Sales Rank: 2377079 ISBN / ASIN: 1588291839 EAN: 9781588291837 Binding: Hardcover Manufacturer: Humana Press Studio: Humana Press Book Description: Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are freeduan.com outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.
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