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Posted on 2010-04-10
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Sequence similarity is a powerful tool for discovering biological function. Just as the ancient Greeks used comparative anatomy to understand the human body and linguists used the Rosetta stone to decipher Egyptian hieroglyphs, today we can use comparative sequence analysis to understand genomes. (Basic Local Alignment Search Tool), is a sophisticated software package for rapid searching of nucleotide and protein databases. It is one of the most important software packages used in sequence analysis and bioinformatics. Most users of , however, seldom move beyond the program& 8217;s default parameters, and never take advantage of its full power. . is the only book completely devoted to this popular suite of tools. It offers biologists, computational biology students, and bioinformatics professionals a clear understanding of as well as the science it supports. This book shows you how to move beyond the default parameters, get specific answers using , and how to interpret your results. The book also contains tutorial and reference sections covering NCBI- and WU-, background material to help you understand the statistics behind , Perl scripts to help you prepare your data and analyze your results, and a wealth of tips and tricks for configuring to meet your own research needs. Some of the topics covered include: . basics and the NCBI web interface . How to select appropriate search parameters . programs: N, P, X, TN, TX, PHI-, and PSI . Detailed references, including NCBI- and WU- . Understanding biological sequences . Sequence similarity, homology, scoring matrices, scores, and evolution . Sequence Alignment . Calculating statistics . Industrial-strength , including developing applications with Perl and . is the only comprehensive reference with detailed, accurate information on optimizing searches for high-throughput sequence analysis. This is a book that any biologist should own. . . Related ArticlesDISCLAIMER:This site does not store Blast on its server. We only index and link to Blast provided by other sites. Please contact the content providers to delete Blast if any and email us, we'll remove relevant links or contents immediately.Comments (0) All |