Health Anticancer drug development guide, 2nd edition (1588292282)

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This unique volume traces the critically important pathway by which a “molecule” becomes an “anticancer agent.” The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. We are still actively engaged in that search today. The question is how to discover these “anticancer” molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute’s high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease.

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	Medical Anticancer Drug Development Anticancer Drug Development Publisher: Academic Press Number Of Pages: 397 Publication Date: 2001-10 Sales Rank: 1467613 ISBN / ASIN: 0120726513 EAN: 9780120726516 Binding: Hardcover Manufacturer: Academic Press Studio: A ...
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