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Programming Ancestral Sequence Reconstruction By David A. Liberles

Posted on 2010-03-16




Name:Programming Ancestral Sequence Reconstruction By David A. Liberles
ASIN/ISBN:0199299188
Language:English
File size:3.23 Mb
Publisher: Oxford University Press
Publish Date: 06-07-2007
ISBN: 0199299188
Pages: 280 pages
File Size: 3.23 Mb
   Programming Ancestral Sequence Reconstruction By David A. Liberles

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Ancestral Sequence Reconstruction By David A. Liberles

Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields. Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including whole proteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized to provide insights and inform future research. This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.

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