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Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry (Techniques and instrumentation in analytical chemistry)

PREFACE

"Such chemistries reside in the night darkness of the molecule that seems

to think ,

The Striders, Loren Eiseley

Loren Eiseley, quoted from "The Striders" in Notes of an Alchemist.

Copyright 1972 Loren Eiseley. Used with permission of Charles

Scribner's Sons.

The brain is one of the most exciting and fertile frontiers of scientific

study. A significant amount of time, experimentation, money, and effort is

being expended in a multi-faceted scientific research effort to unravel the

complexities of the brain. Some of the areas which are being studied include:

how the brain receives, processes, and sends information; how pain is dealt

with in terms of i t s recognition and i t s reduction; anatomical interconnections

among and within brain regions; memory - i t s initial recording, storage, and

recall: creative thought; movement disorders; neuroendocrinology :

neuropsychiatry; dementia; among many other aspects.

Such an area of difficult experimental research necessarily brings into

play a wide variety of basic and clinical scientific disciplines,

subdisciplines, and experimental techniques which involves biologists, medical

personnel, dentists, neurologists, neurochemists, psychiatrists, psychologists,

and analytical chemists. Answers sought to questions regarding the brain's

functioning require elucidation of the molecular processes that operate within

the various brain regions. Only by knowing several aspects of this problem,

such as which molecules are involved, their changing concentrations during

specific physiological events, their precursors and metabolites, and the

enzymatic and regulatory steps which are involved in those transformations,

can we treat the human organism in the normal and pathological states in any

rational and objective manner. Underpinning all of these research efforts are

appropriate analytical tools and techniques which are used to measure the

molecules involved with the maximum level of accuracy, precision, sensitivity,

and molecular specificity. Accuracy is demanded in these four critical

experimental parameters to avoid any confusion or ambiguity in our

experiments, conclusions, hypotheses, experiments, protocols, and

treatments.

Three of the most explosively growing fields in science today include

biologically important peptides, high performance liquid chromatography

(HPLC), and mass spectrometry (MS). Because of the significant advances in

the field of neurobiology , and particular neuropeptides, there now exists

an increasingly critical need for dependable structural information. The

timing is appropriate to review here the pertinent features of these three

areas and to bring into a novel juxtaposition the mutually beneficial aspects

of these areas.

This book is basically oriented towards a review of the literature, but

in those cases where i t is required, more in-depth references will be

suggested to the reader. Papers are selected from the wide spectrum of

available research, briefly reviewed, and presented here to indicate the

panorama of research that is being conducted and to point the way to needed

research,

An effort has been made to remain up-to-date with respect to the

current scientific literature, Because the three fields being discussed

represent some of the most rapidly expanding fields in science today, this

goal is rather difficult to achieve. Towards resolution of this dilemma, a

camera-ready copy is prepared as opposed to a typeset book Buy Book at Lowest Price on Amazon

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