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Lectures on Numerical Methods in Bifurcation Problems
Methods for Finding Zeros in Polynomials
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Educational Psychology by Edward L. Thorndike
The Last Days of Tolstoy by V. G. Chertkov
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A Short Biographical Dictionary of English Literature
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Dollars and Sense by William Crosbie Hunter
The Theory of the Theatre by Clayton Hamilton
The Mathematics of Investment
Occupiers of Wall Street: Losers or Game Changers
The Solution of the Pyramid Problem
Lectures on Moduli of Curves
Walden by Henry David Thoreau
Methods for Finding Zeros in Polynomials
Lectures on Stochastic Flows and Applications
Educational Psychology by Edward L. Thorndike
The Last Days of Tolstoy by V. G. Chertkov
Globalization and Responsibility
Lectures on Siegel Modular Forms and Representation by Quadratic Forms
Lectures on Topics In One-Parameter Bifurcation Problems
History of the Incas by Pedro Sarmiento de Gamboa
Linear Algebra: Theorems and Applications
Lectures on Stochastic Differential Equations and Malliavin Calculus
A Short Biographical Dictionary of English Literature
Lectures on Sieve Methods and Prime Number Theory
Dollars and Sense by William Crosbie Hunter
The Theory of the Theatre by Clayton Hamilton
The Mathematics of Investment
Occupiers of Wall Street: Losers or Game Changers
The Solution of the Pyramid Problem
Lectures on Moduli of Curves
Walden by Henry David Thoreau
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An Introduction to Toxicogenomics
Posted on 2010-04-14
|
More edited by Michael E. Burczynski ISBN: 0849313341 | year 2003 | English Features: • Presents a clear introduction to expression profiling and large scale data analysis applicable to any field of research • Explains the complex clustering algorithms required for expression profiling analyses • Includes stunning images involved in microarray analysis of large-scale data sets • Provides additional information and cites specific examples that illustrate the principles of toxicogenomics • Describes toxicogenomic findings in two of the main model systems employed in toxicological research today • Equally explores concepts and applications in both mechanistic and predictive toxicogenomics Gathering together leading authors and scientists at the forefront of the field, provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors. Contents 1. Fundamentals of Expression Profiling Analysis • Preparation and Utilization of Microarrays • Comparative Studies Using cDNA versus Oligonucleotide Arrays • Quality Control of Expression Profiling Data • An Introduction to Cluster Analysis 2. Expression Profiling and Toxicology: The Advent of Toxicogenomics • Transcriptional Profiling in Toxicology 3. Model Systems in Toxicogenomic Studies • Microarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers • Characterization of Hepatocytes and Their Use as a Model System in Toxicogenomics 4. Mechanistic Toxicogenomics • Molecular Signatures of Dioxin Toxicity Toxicogenomic Dissection of the Antioxidant Response • An Overview of Mechanistic Toxicogenomic Studies 5. Predictive Toxicogenomics • Gene Expression Profile Databases in Toxicity Testing • Predictive Toxicogenomics • Unsupervised Hierarchical Clustering of Toxicants • Toxicogenomic Analysis in Clinical Phamacogenomic Studies 6. The Future of Toxicogenomics • The Future of Toxicogenomics Link : http://rapidshare.de/files/36761828/AItT.rar .
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