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Science/Engineering Advanced Gene Delivery: From Concepts to Pharmaceutical Products (Drug Targeting and Delivery)
Posted on 2010-04-28
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Publisher: CRC (1999) Binding: Hardcover, 314 pages pricer: $189.95 ISBN-10: 9057024381 editorialreviews A practical resource for everyone involved in the gene therapy field and in the design of effective gene delivery systems, this volume presents an overview and update of recent advances in the field of non-viral methods for the in vivo transfer of therapeutic genes to biological targets using conventional routes of administration. Methods to control the spatial and temporal modulation of gene function in vivo as well as the level, duration, specificity, and fidelity of gene expression are described. The rational design and the applications of a variety of non-viral gene delivery systems, such as cationic lipid-, polymer-, and (poly) peptide-based systems, are exemplified for the control of location of therapeutic genes administered by various routes. Current and potential clinical applications of gene-based medicines are presented for the prevention, correction or modulation of diseases. Examples of current applications of plasmid-based systems for genetic vaccination, treatment checked
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