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Basic Skin Histology
Posted on 2010-06-06
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Mark Berryman, Dept. of Biomedical Sciences Ohio University College of Osteopathic Medicine, Athens Protection Sensation Thermoregulation Metabolism Wheater& 8217;sFunctional Histology Layers of Skin 1) Epidermis stratified squamous epithelium epidermal ridges 2) Dermis a) papillary layer small blood vessels, lymph & 038; nerves Dermo-epidermal Junction 1) Hemidesmosome a) germinal cell - keratin filaments -cytoplasmic plaque -plasma membrane -transmembrane linkers 2) Basal lamina a) lamina lucida -anchoring proteins b) lamina densa -crosslinking fibrils 3) Subjacent connective tissue a) collagen fibers b) elastic fibers Basal cell Dermis Wheater& 8217;sFunctional Histology & 8230;.. Wheater& 8217;sFunctional Histology Go Keratin Filaments -dense cytoplasmic bundles -crosslinkedby filaggrin to form large aggregates -concentrated at cell periphery in projections that terminate at desomosomal junctions -crucial for structural integrity, stability, and continuity of the epithelium
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